Can mid-regional pro-adrenomedullin (MR-proADM) increase the prognostic accuracy of NEWS in predicting deterioration in patients admitted to hospital with mild to moderately severe illness? A prospective single-centre observational study.

ABSTRACT:

Objective

To assess the value added to the National Early Warning Score (NEWS) by mid-regional pro-adrenomedullin (MR-proADM) blood level in predicting deterioration in mild to moderately ill people.

Design

Prospective observational study.

Setting

The Medical Admissions Suite of the Royal Victoria Infirmary, Newcastle.

Participants

300 adults with NEWS between 2 and 5 on admission. Exclusion criteria included receiving palliative care, or admitted for social reasons or self-harming. Patients were enrolled between September and December 2015, and followed up for 30 days after discharge.

Outcome measure

The primary outcome measure was the proportion of patients who, within 72 hours, had an acuity increase, defined as any combination of an increase o

SUBMITTER: Graziadio S 

PROVIDER: S-EPMC6278796 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature