The association between insulin therapy and depression in patients with type 2 diabetes mellitus: a meta-analysis.

ABSTRACT:

Objectives

Several patients with type 2 diabetes mellitus (T2DM) have depressive disorders. Whether insulin treatment was associated with increased risk of depression remains controversial. We performed a meta-analysis to evaluate the association of insulin therapy and depression.

Design

A meta-analysis.

Methods

We conducted a systematic search of PubMed, PsycINFO, Embase and the Cochrane Library from their inception to April 2016. Epidemiological studies comparing the prevalence of depression between insulin users and non-insulin users were included. A random-effects model was used for meta-analysis. The adjusted and crude data were analysed.

Results

Twenty-eight studies were included. Of these, 12 studies presented with adjusted ORs. Insulin therapy was signi

SUBMITTER: Bai X 

PROVIDER: S-EPMC6278799 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature