Escherichia coli translation strategies differ across carbon, nitrogen and phosphorus limitation conditions.

ABSTRACT: For cells to grow faster they must increase their protein production rate. Microorganisms have traditionally been thought to accomplish this increase by producing more ribosomes to enhance protein synthesis capacity, leading to the linear relationship between ribosome level and growth rate observed under most growth conditions previously examined. Past studies have suggested that this linear relationship represents an optimal resource allocation strategy for each growth rate, independent of any specific nutrient state. Here we investigate protein production strategies in continuous cultures limited for carbon, nitrogen and phosphorus, which differentially impact substrate supply for protein versus nucleic acid metabolism. Unexpectedly, we find that at slow growth rates, Escherichia coli ac

SUBMITTER: Li SH 

PROVIDER: S-EPMC6278830 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature