Liposomal drug delivery in an in vitro 3D bone marrow model for multiple myeloma.

ABSTRACT:

Purpose

Liposomal drug delivery can improve the therapeutic index of treatments for multiple myeloma. However, an appropriate 3D model for the in vitro evaluation of liposomal drug delivery is lacking. In this study, we applied a previously developed 3D bone marrow (BM) myeloma model to examine liposomal drug therapy.

Material and methods

Liposomes of different sizes (~75-200 nm) were tested in a 3D BM myeloma model, based on multipotent mesenchymal stromal cells, endothelial progenitor cells, and myeloma cells cocultured in hydrogel. The behavior and efficacy of liposomal drug therapy was investigated, evaluating the feasibility of testing liposomal drug delivery in 3D in vitro. Intracellular uptake of untargeted and integrin α₄β₁ (very late antigen-4)

SUBMITTER: Braham MV 

PROVIDER: S-EPMC6278842 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature