Functional chlorin gold nanorods enable to treat breast cancer by photothermal/photodynamic therapy.

ABSTRACT:

Background

The existing chemo/radiotherapy fail to eliminate cancer cells due to the restriction of either drug resistance or radio tolerance. The predicament urges researchers to continuously explore alternative strategy for achieving a potent curative effect.

Methods

Functional chlorin gold nanorods (Ce6-AuNR@SiO₂-d-CPP) were fabricated aiming at treating breast cancer by photothermal/photodynamic therapy (PTT/PDT). The nanostructure was developed by synthesizing Au nanorods as the photothermal conversion material, and by coating the pegylated mesoporous SiO₂ as the shell for entrapping photosensitizer Ce6 and for linking the D-type cell penetrating peptide (d-CPP). The function of Ce6-AuNR@SiO₂-d-CPP was verified on human breast cancer MCF

SUBMITTER: Liu L 

PROVIDER: S-EPMC6278843 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature