Understanding the Factors That Shape Patterns of Nucleotide Diversity in the House Mouse Genome.

ABSTRACT: A major goal of population genetics has been to determine the extent by which selection at linked sites influences patterns of neutral nucleotide diversity in the genome. Multiple lines of evidence suggest that diversity is influenced by both positive and negative selection. For example, in many species there are troughs in diversity surrounding functional genomic elements, consistent with the action of either background selection (BGS) or selective sweeps. In this study, we investigated the causes of the diversity troughs that are observed in the wild house mouse genome. Using the unfolded site frequency spectrum, we estimated the strength and frequencies of deleterious and advantageous mutations occurring in different functional elements in the genome. We then used these estimates to par

SUBMITTER: Booker TR 

PROVIDER: S-EPMC6278861 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature