Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis.

ABSTRACT: The competitive endogenous RNA (ceRNA) hypothesis is an attractively simple model to explain the biological role of many putatively functionless noncoding RNAs. Under this model, there exist transcripts in the cell whose role is to titrate out microRNAs such that the expression level of another target sequence is altered. That it is logistically possible for expression of one microRNA recognition element (MRE)-containing transcript to affect another is seen in the multiple examples of pathogenic effects of inappropriate expression of MRE-containing RNAs. However, the role, if any, of ceRNAs in normal biological processes and at physiological levels is disputed. By comparison of parent genes and pseudogenes we show, both for a specific example and genome-wide, that the pseudo-3' untranslate

SUBMITTER: Glenfield C 

PROVIDER: S-EPMC6278865 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature