Sex Dimorphism in the Myocardial Response to Aortic Stenosis.

ABSTRACT:

Objectives

The goal of this study was to explore sex differences in myocardial remodeling in aortic stenosis (AS) by using echocardiography, cardiac magnetic resonance (CMR), and biomarkers.

Background

AS is a disease of both valve and left ventricle (LV). Sex differences in LV remodeling are reported in AS and may play a role in disease phenotyping.

Methods

This study was a prospective assessment of patients awaiting surgical valve replacement for severe AS using echocardiography, the 6-min walking test, biomarkers (high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide), and CMR with late gadolinium enhancement and extracellular volume fraction, which dichotomizes the myocardium into matrix and cell volumes. LV remodeling was categorized into norma

SUBMITTER: Treibel TA 

PROVIDER: S-EPMC6278887 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature