Evaluation of ¹⁸F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain.

ABSTRACT: The availability of tau PET radioligands enables quantitative assessment of tau density and distribution in the human brain. We evaluated the kinetics of a novel radioligand, ¹⁸F-RO-948 (previously referred to as ¹⁸F-RO6958948), and its ability to identify tau positivity in individual patients with mild Alzheimer disease (AD). Methods: Eleven subjects with amyloid-positive mild AD, 5 amyloid-negative older control subjects (OC), and 5 younger control subjects (YC) completed 1 or 2 (4 AD and 5 OC) PET scans with ¹⁸F-RO-948 for 90, 120, or 200 min. The kinetics of the radioligand was evaluated with standard compartmental and noncompartmental models (with plasma data in 70% of cases), tissue-reference methods, and SUV ratio. These approaches were applie

SUBMITTER: Kuwabara H 

PROVIDER: S-EPMC6278898 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature