Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene.

ABSTRACT:

Background

The relationship among chronic inflammation, innate immunity, and cancer is well established. Mannose-binding lectin (MBL) is a key player in innate immunity. Five polymorphisms in the promoter and first exon of the MBL2 gene alter the expression and function of MBL in humans and are associated with inflammation-related disease susceptibility. These five polymorphisms create six well-characterized haplotypes that result in lower (i.e., LYB, LYC, HYD, and LXA) or higher (i.e., HYA and LYA) serum MBL concentrations. We investigated whether survival of patients with lung cancer was associated with these polymorphisms.

Methods

We used a multivariable Cox proportional hazards model to study the association between MBL2 polymorphisms and their haplotypes and diplotypes

SUBMITTER: Pine SR 

PROVIDER: S-EPMC6278934 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature