CXCL12-CXCR4 signalling plays an essential role in proper patterning of aortic arch and pulmonary arteries.

ABSTRACT:

Aims

Chemokine CXCL12 (stromal derived factor 1: SDF1) has been shown to play important roles in various processes of cardiovascular development. In recent avian studies, CXCL12 signalling has been implicated in guidance of cardiac neural crest cells for their participation in the development of outflow tract and cardiac septum. The goal of this study is to investigate the extent to which CXCL12 signalling contribute to the development of aortic arch and pulmonary arteries in mammals.

Methods and results

Novel Cxcl12-LacZ reporter and conditional alleles were generated. Using whole mount X-gal staining with the reporter allele and vascular casting techniques, we show that the domain branching pattern of pulmonary arteries in Cxcl12-null mice is completely disrupted and disco

SUBMITTER: Kim BG 

PROVIDER: S-EPMC6279073 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature