Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.

ABSTRACT: Aims:The contribution of resident stem or progenitor cells to cardiomyocyte renewal after injury in adult mammalian hearts remains a matter of considerable debate. We evaluated a cell population in the adult mouse heart induced by myocardial infarction (MI) and characterized by an activated Nkx2.5 enhancer element that is specific for multipotent cardiac progenitor cells (CPCs) during embryonic development. We hypothesized that these MI-induced cells (MICs) harbour cardiomyogenic properties similar to their embryonic counterparts. Methods and results:MICs reside in the heart and mainly localize to the infarction area and border zone. Interestingly, gene expression profiling of purified MICs 1 week after infarction revealed increased expression of stem cell markers and embryonic cardiac tra

SUBMITTER: Deutsch MA 

PROVIDER: S-EPMC6279078 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature