Transcriptome signature identifies distinct cervical pathways induced in lipopolysaccharide-mediated preterm birth.

ABSTRACT: With half a million babies born preterm each year in the USA and about 15 million worldwide, preterm birth (PTB) remains a global health issue. Preterm birth is a primary cause of infant morbidity and mortality and can impact lives long past infancy. The fact that there are numerous, and many currently unidentified, etiologies of PTB has hindered development of tools for risk evaluation and preventative therapies. Infection is estimated to be involved in nearly 40% of PTBs of known etiology; therefore, understanding how infection-mediated inflammation alters the cervical milieu and leads to preterm tissue biomechanical changes are questions of interest. Using RNA-seq, we identified enrichment of components involved in inflammasome activation and unique proteases in the mouse cervix during

SUBMITTER: Willcockson AR 

PROVIDER: S-EPMC6279112 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature