KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas.

ABSTRACT:

Objectives

KLHL6 is a recently described BTB-Kelch protein with selective expression in lymphoid tissues and is most strongly expressed in germinal center B cells.

Methods

Using gene expression profiling as well as immunohistochemistry with an anti-KLHL6 monoclonal antibody, we have characterized the expression of this molecule in normal and neoplastic tissues. Protein expression was evaluated in 1,058 hematopoietic neoplasms.

Results

Consistent with its discovery as a germinal center marker, KLHL6 was positive mainly in B-cell neoplasms of germinal center derivation, including 95% of follicular lymphomas (106/112). B-cell lymphomas of non-germinal center derivation were generally negative (0/33 chronic lymphocytic leukemias/small lymphocytic lymphomas, 3/49 marginal

SUBMITTER: Kunder CA 

PROVIDER: S-EPMC6279122 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature