Metabolites Associated With Circulating Interleukin-6 in Older Adults.

ABSTRACT:

Background

Circulating levels of the pro-inflammatory cytokine interleukin-6 (IL-6) levels are elevated in older adults, but mechanisms are unclear. In the current study, we used an untargeted metabolomic approach to develop an improved understanding about mechanisms related to circulating IL-6 in older adults.

Methods

Serum IL-6 values were log-transformed to normalize its distribution. Multivariable-adjusted linear regression was used to examine the association between 324 serum metabolites with log IL-6. Backward elimination linear regression was used to develop a metabolite predictor set representative of log IL-6.

Results

Thirty-six metabolites were significantly associated (p < 0.05 and q < 0.30) with log IL-6 in 73 older adults (average age, 78 years). Metaboli

SUBMITTER: Lustgarten MS 

PROVIDER: S-EPMC6279159 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature