Intravitreal bevacizumab upregulates transthyretin in experimental branch retinal vein occlusion.

ABSTRACT:

Purpose

To identify retinal protein changes that mediate beneficial effects of intravitreal bevacizumab in experimental branch retinal vein occlusion (BRVO).

Methods

In six Danish Landrace pigs, BRVO was induced with argon laser in both eyes. After BRVO was induced, the right eye of each animal was given an intravitreal injection of bevacizumab while the left eye was treated with saline water. The retinas were collected 15 days after BRVO, and differentially expressed proteins were analyzed with tandem mass tags-based mass spectrometry. Validation of statistically significantly changed proteins was performed with immunohistochemistry and western blotting.

Results

Fluorescein angiography showed no recanalization of the occluded vessels. A total of 4,013 proteins were s

SUBMITTER: Cehofski LJ 

PROVIDER: S-EPMC6279196 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature