Gene-based GWAS analysis for consecutive studies of GEFOS.

ABSTRACT: By integrating the multilevel biological evidence and bioinformatics analyses, the present study represents a systemic endeavor to identify BMD-associated genes and their roles in skeletal metabolism.

Introduction

Single-nucleotide polymorphism (SNP)-based genome-wide association studies (GWASs) have already identified about 100 loci associated with bone mineral density (BMD), but these loci only explain a small proportion of heritability to osteoporosis risk. In the present study, we performed a gene-based analysis of the largest GWASs in the bone field to identify additional BMD-associated genes.

Methods

BMD-associated genes were identified by combining the summary statistic P values of SNPs across individual genes in the two consecutive meta-analyses of GWASs from the Gene

SUBMITTER: Zhu W 

PROVIDER: S-EPMC6279247 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature