A Metabolomics Analysis of Body Mass Index and Postmenopausal Breast Cancer Risk.

ABSTRACT:

Background

Elevated body mass index (BMI) is associated with increased risk of postmenopausal breast cancer. The underlying mechanisms, however, remain elusive.

Methods

In a nested case-control study of 621 postmenopausal breast cancer case participants and 621 matched control participants, we measured 617 metabolites in prediagnostic serum. We calculated partial Pearson correlations between metabolites and BMI, and then evaluated BMI-associated metabolites (Bonferroni-corrected α level for 617 statistical tests = P < 8.10 × 10-5) in relation to invasive breast cancer. Odds ratios (ORs) of breast cancer comparing the 90th vs 10th percentile (modeled on a continuous basis) were estimated using conditional logistic regression while controlling for breast cancer risk factors, i

SUBMITTER: Moore SC 

PROVIDER: S-EPMC6279273 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature