Relative Performance of HPV and Cytology Components of Cotesting in Cervical Screening.

ABSTRACT:

Background

The main goal of cervical screening programs is to detect and treat precancer before cancer develops. Human papillomavirus (HPV) testing is more sensitive than cytology for detecting precancer. However, reports of rare HPV-negative, cytology-positive cancers are motivating continued use of both tests (cotesting) despite increased testing costs.

Methods

We quantified the detection of cervical precancer and cancer by cotesting compared with HPV testing alone at Kaiser Permanente Northern California (KPNC), where 1 208 710 women age 30 years and older have undergone triennial cervical cotesting since 2003. Screening histories preceding cervical cancers (n = 623) and precancers (n = 5369) were examined to assess the relative contribution of the cytology and HPV test c

SUBMITTER: Schiffman M 

PROVIDER: S-EPMC6279277 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature