Dataset Information
A novel mouse model of testicular granulosa cell tumors.
Ontology highlight
ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC6279300 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
A novel mouse model of testicular granulosa cell tumors.
Molecular human reproduction 20180701 7
<h4>Study question</h4>What is the role of dysregulated transforming growth factor beta (TGFB) signaling in the development of sex cord-stromal tumors in the testis?<h4>Summary answer</h4>Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs).<h4>What is known already</h4>In an earlier study, we demonstrated that constitutively active TGFB receptor 1 (TGFBR1) in ovarian somatic cells promotes the development of ovarian GrCTs. How ...[more]