Autophagosome-based strategy to monitor apparent tumor-specific CD8 T cells in patients with prostate cancer.

ABSTRACT: The immune system plays an essential role in eradicating cancer in concert with various treatment modalities. In the absence of autologous tumor material, no standardized method exists to assess T cell responses against the many antigens that may serve as cancer rejection antigens. Thus, development of methods to screen for therapy-induced anti-tumor responses is a high priority that could help tailor therapy. Here we tested whether a tumor-derived antigen source called DRibbles®, which contain a pool of defective ribosomal products (DRiPs), long-lived and short-lived proteins (SLiPs) and danger-associated molecular patterns (DAMPs), can be used to identify tumor-associated antigen (TAA)-specific responses in patients before or after immunotherapy treatment. Protein content, gene expressio

SUBMITTER: van de Ven R 

PROVIDER: S-EPMC6279418 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature