Longitudinal association of inflammation with depressive symptoms: A 7-year cross-lagged twin difference study.

ABSTRACT:

Background

The direction of the association between inflammation and depressive symptoms remains inconsistent. The objective of this study was to evaluate the temporal relationship between inflammation and depressive symptoms, and to assess the role of genetic factors on this association.

Methods

In this longitudinal cross-lagged twin difference study, we examined 166 (83 pairs) middle-aged male twins recruited from the Vietnam Era Twin Registry, who were assessed at baseline and after 7 years of follow-up. We assayed plasma levels of two inflammatory biomarkers, interleukin-6 (IL-6) and high sensitivity C-reactive protein (CRP) and measured depressive symptoms using the Beck Depression Inventory-II (BDI). To evaluate the direction of the association, we constructed multivar

SUBMITTER: Huang M 

PROVIDER: S-EPMC6279462 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature