Increased risk of anal squamous cell carcinoma in HIV-positive men with prior hepatitis B virus infection.

ABSTRACT:

Objective(s)

HIV-positive individuals have elevated rates of anal squamous cell carcinoma (SCC), and sexually transmitted infections with its causative agent, high-risk human papillomavirus, and other oncoviruses including hepatitis B virus (HBV). HBV infection can cause liver cancer, and has been associated with increased risk of some extra-hepatic cancers including biliary tract cancer, pancreatic cancer, and non-Hodgkin lymphoma. Whether HBV is associated with anal SCC risk is unknown.

Design

Prospective study of anal SCC risk in HIV-positive and HIV-negative MSM in the Multicenter AIDS Cohort Study from 1984 to 2014.

Methods

Poisson regression models were used to examine the association between past or current HBV infection (positive tests for HBV core antibodies,

SUBMITTER: Aldersley J 

PROVIDER: S-EPMC6279494 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature