Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial.

ABSTRACT:

Background

Among women, trichomoniasis is the most common non-viral sexually transmitted infection worldwide, and is associated with serious reproductive morbidity, poor birth outcomes, and amplified HIV transmission. Single-dose metronidazole is the first-line treatment for trichomoniasis. However, bacterial vaginosis can alter treatment efficacy in HIV-infected women, and single-dose metronidazole treatment might not always clear infection. We compared single-dose metronidazole with a 7-day dose for the treatment of trichomoniasis among HIV-uninfected, non-pregnant women and tested whether efficacy was modified by bacterial vaginosis.

Methods

In this multicentre, open-label, randomised controlled trial, participants were recruited at three sexual health clinics in the USA.

SUBMITTER: Kissinger P 

PROVIDER: S-EPMC6279510 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature