Corpus callosum low-frequency stimulation suppresses seizures in an acute rat model of focal cortical seizures.

ABSTRACT:

Objective

Low-frequency fiber-tract stimulation has been shown to be effective in treating mesial temporal lobe epilepsies through activation of the hippocampal commissure in rodents and human patients. The corpus callosum is a major pathway connecting the two hemispheres of the brain; however, few experiments have documented corpus callosum stimulation. The objective is to determine the efficacy of corpus callosum stimulation at low frequencies to suppress cortical seizures.

Methods

4-Aminopyridine was injected in the primary motor cortex of 24 rats under anesthesia. Recording electrodes were placed in the contralateral motor cortex and hippocampus. Three pairs of stimulating electrodes were inserted into the corpus callosum along its longitudinal axis. Local field potentia

SUBMITTER: Couturier NH 

PROVIDER: S-EPMC6279515 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature