Impact of prior local therapy on overall survival in men with metastatic castration-resistant prostate cancer: Results from Shared Equal Access Regional Cancer Hospital.

ABSTRACT:

Objectives

To evaluate the impact of previous local treatment on survival in men with newly diagnosed metastatic castration-resistant prostate cancer.

Methods

We carried out a retrospective study of patients newly diagnosed with metastatic castration-resistant prostate cancer in the year 2000 or later from eight Veterans Affairs Medical Centers. Patients were categorized based on prior local therapy (none, prostatectomy ± radiation or radiation alone). Overall and cancer-specific survival was estimated by the Kaplan-Meier method. Cox proportional hazards regression models were used to test the association between prior local treatment and survival.

Results

Of 729 patients, 284 (39%) underwent no local treatment, 176 (24%) underwent radical prostatectomy ± radiation an

SUBMITTER: Patel DN 

PROVIDER: S-EPMC6279517 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature