Chronic Medical Conditions and CA125 Levels among Women without Ovarian Cancer.

ABSTRACT:

Background

Randomized trials using the biomarker cancer antigen (CA) 125, with or without pelvic ultrasound, have failed to show a clear benefit of general population screening for ovarian cancer. In part, this may be due to a lack of information about conditions, besides ovarian cancer, that can alter CA125 levels and affect specificity or sensitivity. We evaluated the association between common medical conditions and CA125 levels among women without ovarian cancer.

Methods

We used data and specimens from 2,004 women without ovarian cancer who participated in the New England Case Control study between 1992 and 2008. Participants completed in-person interviews and donated blood samples at enrollment. We measured CA125 using the CA125II assay and calculated the association be

SUBMITTER: Akinwunmi BO 

PROVIDER: S-EPMC6279537 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature