Determinants of skeletal muscle protein turnover following severe burn trauma in children.

ABSTRACT: BACKGROUND & AIMS:Burns remain the fifth cause of non-fatal pediatric injuries globally, with muscle cachexia being a hallmark of the stress response to burns. Burn-induced muscle wasting is associated with morbidity, yet the determinants of muscle protein catabolism in response to burn trauma remains unclear. Our objective was to determine the effect of patient and injury characteristics on muscle protein kinetics in burn patients. METHODS:This retrospective, observational study was performed using protein kinetic data from pediatric patients who had severe burns (>30% of the total body surface area burned) and underwent cross-limb stable isotope infusions between 1999 and 2008 as part of prospective clinical trials. Mixed multiple regression models were used to assess associations betwee

SUBMITTER: Malagaris I 

PROVIDER: S-EPMC6279601 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature