Risk of Hepatocellular Cancer in Patients With Non-Alcoholic Fatty Liver Disease.

ABSTRACT:

Background & aims

There are limited data on the risk of hepatocellular cancer (HCC) in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to estimate the risk of incident HCC among patients with NAFLD.

Methods

We conducted a retrospective cohort study from a total of 130 facilities in the Veterans Health Administration. Patients with NAFLD diagnosed between January 1, 2004 and December 31, 2008 were included and followed until HCC diagnosis, death, or December 31, 2015. We also identified a sex- and age-matched control cohort without NAFLD. We ascertained all new HCC cases from the Central Cancer Registry and manual chart reviews. We calculated incidence rates for HCC by NAFLD status, as well as in subgroups of NAFLD patients. We used competing risk models to

SUBMITTER: Kanwal F 

PROVIDER: S-EPMC6279617 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature