High-performance reconstruction of microscopic force fields from Brownian trajectories.

ABSTRACT: The accurate measurement of microscopic force fields is crucial in many branches of science and technology, from biophotonics and mechanobiology to microscopy and optomechanics. These forces are often probed by analysing their influence on the motion of Brownian particles. Here we introduce a powerful algorithm for microscopic force reconstruction via maximum-likelihood-estimator analysis (FORMA) to retrieve the force field acting on a Brownian particle from the analysis of its displacements. FORMA estimates accurately the conservative and non-conservative components of the force field with important advantages over established techniques, being parameter-free, requiring ten-fold less data and executing orders-of-magnitude faster. We demonstrate FORMA performance using optical tweezers, sh

SUBMITTER: Perez Garcia L 

PROVIDER: S-EPMC6279749 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature