Bovine neutrophils form extracellular traps in response to the gastrointestinal parasite Ostertagia ostertagi.

ABSTRACT: Ostertagia ostertagi (OO) is a widespread parasite that causes chronic infection in cattle and leads to annual losses of billions of dollars in the cattle industry. It remains unclear why cattle are unable to mount an effective immune response despite a large influx of immune cells to the infected abomasal mucosa and draining lymph nodes. Neutrophils, the immune system's first responders, have the capacity to release neutrophil extracellular traps (NETs) to contain various pathogens, including some parasites. In the present study, the mechanisms by which O. ostertagi influences bovine NET formation were investigated. O. ostertagi larval soluble extract (OO extract) was able to induce typical NETs by purified neutrophils in vitro, confirmed by co-localization of extracellular DNA with typic

SUBMITTER: Mendez J 

PROVIDER: S-EPMC6279769 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature