Shared genetic aetiology between cognitive performance and brain activations in language and math tasks.

ABSTRACT: Cognitive performance is highly heritable. However, little is known about common genetic influences on cognitive ability and brain activation when engaged in a cognitive task. The Human Connectome Project (HCP) offers a unique opportunity to study this shared genetic etiology with an extended pedigree of 785 individuals. To investigate this common genetic origin, we took advantage of the HCP dataset, which includes both language and mathematics activation tasks. Using the HCP multimodal parcellation, we identified areals in which inter-individual functional MRI (fMRI) activation variance was significantly explained by genetics. Then, we performed bivariate genetic analyses between the neural activations and behavioral scores, corresponding to the fMRI task accuracies, fluid intelligence, w

SUBMITTER: Le Guen Y 

PROVIDER: S-EPMC6279777 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature