Seroepidemiological investigation of HAdV-4 infection among healthy adults in China and in Sierra Leone, West Africa.

ABSTRACT: An apparent increase in the frequency of human adenovirus type 4 (HAdV-4) infections among general populations has been observed over the past 10 years. However, available epidemiological data that may reflect previous viral circulation and assist in predicting potential outbreaks are sparse, particularly in mainland China and Africa. In this study, a convenient neutralization assay for use in the surveillance of historical HAdV-4 infections was established based on a recombinant luciferase-expressing virus. Subsequently, the neutralizing antibodies (nAbs) of 1013 healthy adult serum samples from China and Sierra Leone were evaluated. Our results showed that over 50% of the participants from China and nearly 70% of donors from Sierra Leone had detectable nAbs against HAdV-4 despite the few

SUBMITTER: Wang B 

PROVIDER: S-EPMC6279822 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature