Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naive Patients With Obsessive-Compulsive Disorder.

ABSTRACT: Obsessive-compulsive disorder (OCD) patients have difficulty in switching between obsessive thought and compulsive behavior, which may be related to the dysfunction of the salience network (SN). However, little is known about the changes in intra- and inter- intrinsic functional connectivity (iFC) of the SN in patients with OCD. In this study, we parceled the SN into 19 subregions and investigated iFC changes for each of these subregions in 40 drug-naïve patients with OCD and 40 healthy controls (HCs) using seed-based functional connectivity resting-state functional magnetic resonance imaging (rs-fMRI). We found that patients with OCD exhibited decreased iFC strength between subregions of the SN, as well as decreased inter-network connectivity between SN and DMN, and ECN. These findings hi

SUBMITTER: Chen YH 

PROVIDER: S-EPMC6279930 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature