Sleep and circadian rhythm disruption and stress intersect in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) was discovered and the pathological hallmarks were revealed more than a century ago. Subsequently, many remarkable discoveries and breakthroughs provided us with mechanistic insights into the pathogenesis of AD. The identification of the molecular underpinning of the disease not only provided the framework of AD pathogenesis but also targets for therapeutic inventions. Despite all the initial successes, no effective treatment for AD has emerged yet as all the late stages of clinical trials have failed. Many factors ranging from genetic to environmental factors have been critically appraised as the potential causes of AD. In particular, the role of stress on AD has been intensively studied while the relationship between sleep and circadian rhythm disruption (SCRD) a

SUBMITTER: Phan TX 

PROVIDER: S-EPMC6279965 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature