Gut microbial features can predict host phenotype response to protein deficiency.

ABSTRACT: Malnutrition remains a major health problem in low- and middle-income countries. During low protein intake, <0.67 g/kg/day, there is a loss of nitrogen (N₂ ) balance, due to the unavailability of amino acid for metabolism and unbalanced protein catabolism results. However, there are individuals, who consume the same low protein intake, and preserve N₂ balance for unknown reasons. A novel factor, the gut microbiota, may account for these N₂ balance differences. To investigate this, we correlated gut microbial profiles with the growth of four murine strains (C57Bl6/J, CD-1, FVB, and NIH-Swiss) on protein deficient (PD) diet. Results show that a PD diet exerts a strain-dependent impact on growth and N₂ balance as determined through analysis of urina

SUBMITTER: Navarro G 

PROVIDER: S-EPMC6280014 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature