Comparative proteomic analysis of normal and gliotic PVR retina and contribution of Muller glia to this profile.

ABSTRACT: Müller glia are responsible for the neural retina regeneration observed in fish and amphibians throughout life. Despite the presence of these cells in the adult human retina, there is no evidence of regeneration occurring in humans following disease or injury. It may be possible that factors present in the degenerated retina could prevent human Müller glia from proliferating and neurally differentiating within the diseased retina. On this basis, investigations into the proteomic profile of these cells and the abundance of key proteins associated to Müller glia in the gliotic PVR retina, may assist in the identification of factors with the potential to control Müller proliferation and neural differentiation in vivo. Label free mass spectrometry identified 1527 proteins in Müller glial cell

SUBMITTER: Eastlake K 

PROVIDER: S-EPMC6280037 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature