Survival impact of postoperative radiotherapy timing in pediatric and adolescent medulloblastoma.

ABSTRACT: Background:Radiation therapy (RT) remains a critical component of multimodality treatment for medulloblastoma. Traditionally, clinicians strive to start RT within 4-5 weeks of surgery, but the optimal timing after surgery remains unclear. Methods:Using the National Cancer Database, we identified pediatric and adolescent patients with medulloblastoma treated with curative-intent surgery, RT, and chemotherapy. Factors associated with early or delayed RT were identified using Pearson chi-squared tests. Overall survival (OS) differences based on RT timing were compared using the Kaplan-Meier estimator with log-rank tests. Patient, tumor, and treatment characteristics associated with OS were analyzed with univariate and multivariate Cox proportional hazards models. Results:Among the 1338 patien

SUBMITTER: Chin AL 

PROVIDER: S-EPMC6280134 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature