Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients.

ABSTRACT:

Background

The gut microbiota is altered in patients with chronic kidney disease (CKD), and cardiovascular risk increases with progressive CKD. This study examined the potential link between short chain fatty acids (SCFAs), which are produced by the gut microbiota, and cardiovascular outcomes in patients with CKD.

Methods

SCFAs were measured using a targeted liquid chromatography-mass spectrometry platform in baseline plasma samples from 214 patients with CKD enrolled in the Clinical Phenotyping Resource and Biobank Core; 81 patients with coronary artery disease (CAD) and 133 without CAD were randomly assigned to training and validation subsets. The primary outcome was a history of CAD and the secondary outcome was a composite history of cardiovascular disease (CVD) at enrol

SUBMITTER: Jadoon A 

PROVIDER: S-EPMC6280192 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature