Desmoplastic nodular medulloblastoma in young children: a management dilemma.

ABSTRACT:

Background

Children with desmoplastic nodular medulloblastoma (DNMB) have excellent survival, leading multiple groups globally to attempt reduction of treatment-related morbidity. In 2013, the Children's Oncology Group began a clinical trial (ACNS1221) eliminating both radiation therapy (RT) and intraventricular methotrexate for children under 3 years of age with localized DNMB, aiming to build upon the excellent outcomes of the German HIT trials. ACNS1221 has recently closed due to increased incidence of recurrences noted at the 2-year interim analysis, raising important questions regarding optimal therapy for DNMB.

Methods

A review of major clinical trials that included children with DNMB was performed through July 2017.

Results

One hundred and eighty-eight DNMB pat

SUBMITTER: AbdelBaki MS 

PROVIDER: S-EPMC6280315 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature