Automated generation of genome-scale metabolic draft reconstructions based on KEGG.

ABSTRACT:

Background

Constraint-based modeling is a widely used and powerful methodology to assess the metabolic phenotypes and capabilities of an organism. The starting point and cornerstone of all such modeling is a genome-scale metabolic network reconstruction. The creation, further development, and application of such networks is a growing field of research thanks to a plethora of readily accessible computational tools. While the majority of studies are focused on single-species analyses, typically of a microbe, the computational study of communities of organisms is gaining attention. Similarly, reconstructions that are unified for a multi-cellular organism have gained in popularity. Consequently, the rapid generation of genome-scale metabolic reconstructed networks is crucial. While mul

SUBMITTER: Karlsen E 

PROVIDER: S-EPMC6280343 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature