The expression of EMX2 lead to cell cycle arrest in glioblastoma cell line.

ABSTRACT:

Background

Glioblastoma (GB) is a highly invasive primary brain tumor that nearly always systematically recurs at the site of resection despite aggressive radio-chemotherapy. Previously, we reported a gene expression signature related to tumor infiltration. Within this signature, the EMX2 gene encodes a homeodomain transcription factor that we found was down regulated in glioblastoma. As EMX2 is reported to play a role in carcinogenesis, we investigated the impact of EMX2 overexpression in glioma-related cell lines.

Methods

For that purpose, we constructed tetracycline-inducible EMX2 expression lines. Transfected cell phenotypes (proliferation, cell death and cell cycle) were assessed in time-course experiments.

Results

Restoration of EMX2 expression in U87 glioblasto

SUBMITTER: Monnier A 

PROVIDER: S-EPMC6280364 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature