Establishment of a Chinese street rabies virus library and its application for detecting neutralizing activity.

ABSTRACT:

Background

The injection of rabies immune globulin (RIG) is of the utmost importance in the management of category III exposures to rabies-suspect animals. Because of the high cost and limited availability of existing RIG, one possible replacement for RIG is monoclonal antibodies (MAbs) against the rabies virus (RABV). Consequently, it is necessary to determine the neutralizing activity of the MAbs against rabies viruses, especially street rabies virus. However, the method to detect the neutralizing activity of MAbs against street rabies virus remains undefined.

Methods

To establish a method for detecting the neutralizing activity of MAbs against street rabies virus, we constructed a library consisting of 12 strains of street RABV from 11 provinces in China. Using this stree

SUBMITTER: Yu PC 

PROVIDER: S-EPMC6280407 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature