A systematic review of the association between delayed appropriate therapy and mortality among patients hospitalized with infections due to Klebsiella pneumoniae or Escherichia coli: how long is too long?

ABSTRACT:

Background

Temporal relationships between the time to appropriate antibiotic therapy and outcomes are not well described.

Methods

A systematic literature review and meta-analysis was performed to examine this relationship in patients hospitalized with Klebsiella pneumoniae or Escherichia coli infections.

Results

Twenty identified studies contained data for patients who received delayed appropriate therapy (DAT) versus appropriate antibiotic therapy for these pathogens. Of the 20 included studies, the majority (19/20) focused on patients with bloodstream infections, and only 1 study evaluated patients with pneumonia. When all DAT results were combined (any delay > 24 h from culture collection or any delay after culture and susceptibility reporting [C& SR]), there was a

SUBMITTER: Lodise TP 

PROVIDER: S-EPMC6280436 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature