Uniqueness of local myocardial strain patterns with respect to activation time and contractility of the failing heart: a computational study.

ABSTRACT:

Background

Myocardial deformation measured by strain is used to detect electro-mechanical abnormalities in cardiac tissue. Estimation of myocardial properties from regional strain patterns when multiple pathologies are present is therefore a promising application of computer modelling. However, if different tissue properties lead to indistinguishable strain patterns ('degeneracy'), the applicability of any such method will be limited. We investigated whether estimation of local activation time (AT) and contractility from myocardial strain patterns is theoretically possible.

Methods

For four different global cardiac pathologies local myocardial strain patterns for 1025 combinations of AT and contractility were simulated with a computational model (CircAdapt). For each strain

SUBMITTER: Kirn B 

PROVIDER: S-EPMC6280493 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature