Asymmetric synthesis of aminochromanes via intramolecular indium-mediated allylation of chiral hydrazones.

ABSTRACT: The asymmetric intramolecular indium-mediated cyclization reaction delivers chromanes with excellent diastereoselectivity (68-91% yield, dr >99:1). The reaction was efficient for aryl substrates with both electron-withdrawing and -donating groups. Carboxylic acid additives were found to be necessary for optimal reaction.

SUBMITTER: Samanta D 

PROVIDER: S-EPMC6280656 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature