A hidden Markov random field-based Bayesian method for the detection of long-range chromosomal interactions in Hi-C data.

ABSTRACT:

Motivation

Advances in chromosome conformation capture and next-generation sequencing technologies are enabling genome-wide investigation of dynamic chromatin interactions. For example, Hi-C experiments generate genome-wide contact frequencies between pairs of loci by sequencing DNA segments ligated from loci in close spatial proximity. One essential task in such studies is peak calling, that is, detecting non-random interactions between loci from the two-dimensional contact frequency matrix. Successful fulfillment of this task has many important implications including identifying long-range interactions that assist interpreting a sizable fraction of the results from genome-wide association studies. The task - distinguishing biologically meaningful chromatin interactions from massi

SUBMITTER: Xu Z 

PROVIDER: S-EPMC6280722 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature