Damage-responsive elements in Drosophila regeneration.

ABSTRACT: One of the most important questions in regenerative biology is to unveil how and when genes change expression and trigger regeneration programs. The resetting of gene expression patterns during response to injury is governed by coordinated actions of genomic regions that control the activity of multiple sequence-specific DNA binding proteins. Using genome-wide approaches to interrogate chromatin function, we here identify the elements that regulate tissue recovery in Drosophila imaginal discs, which show a high regenerative capacity after genetically induced cell death. Our findings indicate there is global coregulation of gene expression as well as a regeneration program driven by different types of regulatory elements. Novel enhancers acting exclusively within damaged tissue coope

SUBMITTER: Vizcaya-Molina E 

PROVIDER: S-EPMC6280756 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature