Genomics and clinical correlates of renal cell carcinoma.

ABSTRACT:

Purpose

Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have now been well characterised thanks to large collaborative projects such as The Cancer Genome Atlas (TCGA). Not only has knowledge of the genomic landscape helped inform the development of new drugs, it also promises to fine tune prognostication.

Methods

A literature review was performed summarising the current knowledge on the genetic basis of RCC.

Results

The Von Hippel-Lindau (VHL) tumour suppressor gene undergoes bi-allelic knockout in the vast majority of clear cell RCCs. The next most prevalent aberrations include a cohort of chromatin-modifying genes with diverse roles including PBRM1, SETD2, BAP1, and KMD5C. The most common non-clear cell renal cancers have also undergone geno

SUBMITTER: Mitchell TJ 

PROVIDER: S-EPMC6280817 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature