Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Visual Evoked Potential.

ABSTRACT:

Background

Multifocal visual evoked potential (MF-VEP) assesses a wider visual field than full-field VEP (FF-VEP) and potentially offers a more precise analysis of optic nerve injury and repair following optic neuritis. MF-VEP may offer advantages over FF-VEP as an endpoint in clinical trials of remyelinating therapies.

Objective

MF-VEP testing was used to study changes in visual pathways in 48% of RENEW [phase II, opicinumab (anti-LINGO-1; BIIB033) vs. placebo after first acute unilateral optic neuritis] participants.

Methods

This exploratory MF-VEP RENEW substudy compared mean outcomes at weeks 24 and 32 among participants in the intent-to-treat (ITT; n = 39; 72% female; mean age: 32.3 years) and per-protocol (PP; n = 31; 71% female; mean age: 32.2 years) population

SUBMITTER: Klistorner A 

PROVIDER: S-EPMC6280853 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature